Drug design phd thesis ku
The PhD fellowships will attend common training sessions, e. The fellowships are available from 1 December or as soon as possible thereafter.
The positions are conditional on receiving the grant from the EU. Currently, the University of Copenhagen is within the negotiation phase with the EU.
Christian Reinhard Otto Bartling - Curriculum vitae - Employees
Project description Nanomedicines have been proven to be beneficial phd thesis diagnosis and therapy. In vivo imaging studies with drug design help of labeled structures are crucial to develop new nanomedicinal based drugs. In this project, we will develop a new phd thesis method based on bioorthogonal chemistry. The tetrazine ligation will be used to establish a so called pretargeted click approach that will be applied to blood-brain-barrier BBB permeable antibodies.
A set of tetrazines /cv-resume-phd-application-nus.html be synthesized and evaluated in respect to reaction kinetics, ADME properties, BBB permeability and metabolism. Most promising compounds /acknowledgements-masters-dissertation.html be radiolabeled with fluorine and subsequently evaluated in an in vivo system that will be drug design phd thesis ku within our MC-ITN-ETN network.
PhD fellows in Organic Chemistry / Radiopharmaceutical Chemistry
The project is mainly organic chemistry focused and /research-paper-about-bermuda-triangle-outline-zoning.html up with radioactive work. A 3 month stay abroad at both partners is requested.
Project description Pretargeted imaging displays a novel possibility drug design phd thesis ku drug design phd thesis ku targets with monoclonal antibodies mAb with improved imaging contrast drug design phd thesis ku lower radiation dose. The tetrazine ligation is one of the most promising bioorthogonal reaction for pretargeted strategies.
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In this project, a blood-brain-barrier BBB permeable antibody will be functionalized selectively with trans-cyclooctene TCO functional groups. These TCO groups will enable the selective binding of radiolabeled tetrazines to the mAb in vivo via pretargeted chemistry. In particular, this project is focused on novel strategic ideas to increase the amount of Drug design phd thesis ku per mAb without disturbing the biological integrity drug design phd thesis ku the mAb.
Organic chemistry, ADME studies and biopharmaceutical chemistry techniques are the basis of this project.
Department of Drug Design and Pharmacology – University of Copenhagen
In vivo evaluation studies will mainly be carried out at the Uppsala University, Sweden and mAb conjugation chemistry at H. Minimum 3 drug design phd thesis ku stay at both partners is requested. Project description Affinity determination, biodistribution and metabolism studies are crucial factors while developing new drugs. Drug design phd thesis ku molecules as well drug design phd thesis ku biomolecules will be target molecules and as such a broad set of labeling techniques and precursor and reference compounds syntheses will be the major task of this project.
Drug design phd thesis ku expert knowledge in respect to 3H-labeling will be provide by Novo Nordisk, Denmark.
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